To evaluate the individual risk and relative risk of prognostic factors in survival after resection of primary hepatoma, 128 patients with hepatic resection were retrospectively reviewed over an 8 year period from January, 1985 to December. 1992
at
Yonsei Medical Center.
Univariate analysis disclosed that age (p=0.28), sex (p=0.91), ICG Rmax (p=0.86), ICG R15 (p=0.43), Child-Pugh classification (p=0.35), preoperative prothrombin time (p=0.55), preoperative chemotherapy (p=0.42), tumor capsule (p=0.06), resection
margin
(p=0.08) and liver cirrhosis (p=0.46) had no statistically significant effect on survival but lymph node metastasis (p=0.001), tumor size (p=0.002), capsular invasion (p=0.003) showed significant differences in survival.
A multivariate survival analysis using Cox's proportional hazard model revealed that the presence or lymph node metastasis was the most significant prognostic factor followed by the presence of capsular invasion and preoperative serum-AFP levels
in
decreasing order of significance.
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